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LIU Wei,HU Jun-dong,YANG Hong-xia,CHEN Jun-liang.Research Progress on Elemental Speciation Analysis by Inductively Coupled Plasma-Mass Spectrometry Hyphenated Techniques[J].Rock and Mineral Analysis,2021,(3):327-339
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Research Progress on Elemental Speciation Analysis by Inductively Coupled Plasma-Mass Spectrometry Hyphenated Techniques
Received:June 11, 2020  Revised:December 21, 2020
DOI:10.15898/j.cnki.11-2131/td.202006110089
Key words: GC-ICP-MS  CE-ICP-MS  IC-ICP-MS  HPLC-ICP-MS  hyphenated technique  elemental speciation
Author NameAffiliation
LIU Wei National Research Center for Geoanalysis, Key Laboratory of Element Microareas and Speciation Analysis, China Geological Survey, Beijing 100037, China 
HU Jun-dong National Research Center for Geoanalysis, Key Laboratory of Element Microareas and Speciation Analysis, China Geological Survey, Beijing 100037, China 
YANG Hong-xia China Geological Survey, Beijing 100037, China 
CHEN Jun-liang Institute of Nuclear Safety, China Institute of Atomic Energy, Beijing 102413, China 
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Abstract:
      BACKGROUND: As a highly sensitive analytical technique, ICP-MS has been widely used in the analysis of trace inorganic elements. Combined with chromatographic separation technology, it provides a powerful detection tool for elemental speciation analysis.
OBJECTIVES: To summarize the research progress of elemental speciation analysis by inductively coupled plasma mass spectrometry hyphenated techniques.
METHODS: The main methods of elemental speciation analysis by ICP-MS hyphenated techniques were summarized and compared. The methods included:(1) Gas chromatography coupled with ICP-MS (GC-ICP-MS). (2) Capillary electrophoresis coupled with ICP-MS (CE-ICP-MS). (3) Ion chromatography coupled with ICP-MS (IC-ICP-MS). (4) High performance liquid chromatography coupled with ICP-MS (HPLC-ICP-MS). The main application fields of elemental speciation analysis in China were biomedical field, food and drug safety monitoring and ecoenvironmental geochemistry.
RESULTS: GC-ICP-MS has high sensitivity and is suitable for volatile samples, its application is thus limited. CE-ICP-MS has fast analysis and high separation efficiency, but the limitation of sample injection volume makes the method detection limitation high. IC-ICP-MS mainly analyzes anions, cations and small molecular polar compounds. It is a useful complement to HPLC, but the mobile phase containing inorganic salts may block the sampling cone. HPLC-ICP-MS has been the most widely used technology in speciation analysis because of its wide application fields and simple technology.
CONCLUSIONS: Sample preparation research for complex matrices, preparing standard materials, and developing simultaneous multi-element speciation analysis methods are the research direction of elemental speciation analysis.